Nature, Published online: 25 February 2026; doi:10.1038/d41586-026-00584-y
These gene variants can affect men and women, increasing the risk of a range of cancers, including prostate, breast and ovarian cancer.
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For implementers, the locking model adds a fair amount of non-trivial internal bookkeeping. Every operation must check lock state, readers must be tracked, and the interplay between locks, cancellation, and error states creates a matrix of edge cases that must all be handled correctly.